Venous stasis and activation of coagulation
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Thrombophilia states and markers of coagulation activation in the prediction of pediatric venous thromboembolic outcomes: a comparative analysis with respect to adult evidence.
Venous thromboembolism (VTE) in children is an important clinical concern for which risk factors include clinical conditions that incite venous stasis, endothelial damage, or thrombophilia (i.e., hypercoagulability) states. Acquired thrombophilia and markers of coagulation activation are common in pediatric VTE, while potent genetic thrombophilia states are less frequently encountered; neverthe...
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Background As for other pathologies, the pathogenesis of venous thrombo-embolism (VTE) is multifactorial. A comprehensive understanding of the pathogenesis of venous thrombosis is essential for identifying patients at increased risk as in elderly patients with congestive heart failure (CHD) and with presence of chronic venous insufficiency (IVC). Eberhard Mammen postulated immobility as the lea...
متن کاملAnticoagulant drugs in the elderly: valuable in selected patients.
Taken together, venous and arterial thromboembolism form the commonest causes of death, admission to hospital, and physical disability in the second half of life. Their incidence, prevalence, and mortality all increase steeply with age. The mechanisms are not known but may include changes related to age, such as increased concentrations of clotting factors,' increased activation of coagulation ...
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Orthostatic stress causes significant plasma shift and raises transmural pressure in lower extremities, resulting in an increase in endothelial activation and plasma proteins concentrations, possibly including coagulation factors. This may lead to activation of the coagulation system during standing. To test this hypothesis, we recruited 18 healthy volunteers (9 females and 9 males; mean age: 2...
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BACKGROUND There is widespread concern that laparoscopic procedures that are usually performed under general anesthesia, using muscle relaxation, in a reverse Trendelenberg position and with pneumoperitoneum, may lead to venous stasis in lower limbs. OBJECTIVE To evaluate perioperative changes in the venous system and determine the frequency of deep venous thrombosis associated with minimally...
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